Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• -loaded gelatin nanoparticles imaged in the quantitative imaging mode with a JPK NanoWizard III in Milli-Q® water at 37 °C, as well as the extracted Young’s modulus map as previously described [22] (Figure 1). Takechi-Haraya et al. showed that for liposomes both methods deliver the same results [21]. The

• or surface potentials are determined, we would suggest to prioritize the determination of the Young’s modulus. This is due to the advantage of comparable fast acquisition and the mapping option. From our own data on gelatin nanoparticles, we can say that introducing pause segments during the

• convinced that elasticity as a formulation parameter can help to promote more nanoparticulate drug delivery systems to be translated to the clinics. (A) Height image of gelatin nanoparticles on a silica surface imaged in Milli-Q® water at 37 °C in the quantitative imaging mode. (B) A force–distance curve

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• tumor site, showing facilitated diffusion through tumor tissue due to their smaller size and specific surface engineering [111]. Wong et al. developed a multistage system with facilitated tumor diffusive transport composed of 100 nm gelatin nanoparticles, capable of releasing 10 nm NPs from their

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

• Agnes-Valencia Weiss,
• Daniel Schorr,
• Julia K. Metz,
• Metin Yildirim,
• Saeed Ahmad Khan and
• Marc Schneider

Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68

• nanoparticles (GNPs). Furthermore, we introduce the possibility of tuning the elastic properties of gelatin nanoparticles during their preparation through crosslinking time. Young’s moduli from 5.48 to 14.26 MPa have been obtained. Additionally, the possibility to measure the elasticity of single nanoparticles

• . Keywords: atomic force microscopy; drug delivery; elasticity; gelatin nanoparticles; Young’s modulus; Introduction Developing nanoparticulate drug carriers for various diseases and application routes requires establishing controllable systems, matching the needs of the respective application to achieve

• evaluated during the formulation development and tuned according to the requirements of the target. Gelatin nanoparticles (GNPs) were introduced as potential biocompatible and biodegradable drug carrier system [10][11]. This hydrogel nanoparticulate carrier system shows great potential for the delivery of

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

• Xiaoyan Ma,
• Haoning Gong,
• Kenji Ogino,
• Xuehai Yan and
• Ruirui Xing

Beilstein J. Nanotechnol. 2022, 13, 284–291, doi:10.3762/bjnano.13.23

• antioxidant peptides by proteases. The combination of liposomes or polymers with different payload materials has been reported, for example, PEG-modified liposomes loaded with resveratrol, layer-by-layer-coated gelatin nanoparticles, or Gelucire-based solid lipid and polymeric micelles [14][15][16][17][18][19